DEFINITION
A platelet count above the upper end of the reference range
Purdue University Teaching Hospital reference ranges—dogs, 200,000–900,000/mL; cats, 300,000–700,000/mL
PATHOPHYSIOLOGY
Can be caused by overproduction of platelets, decreased clearance of platelets, and decreased sequestration of platelets.
Overproduction occurs secondary to bone marrow stimulation by thrombopoietin and factors such as IL-1, IL-3, IL-6, and IL-11.
For most associated diseases, the exact mechanisms are not well documented.
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