OVERVIEW
Respiratory enteric orphan virus (reovirus)—genus in the family Reovirus; nonenveloped, double-stranded RNA virus; isolated from respiratory and enteric tracts; not associated with any known disease (hence orphan)
Ubiquitous in geographic distribution and host range, virtually every species of mammal, including humans
Virus—infects mature epithelial cells on luminal tips of the intestinal villi; causes cellular destruction, resulting in villous atrophy (similar to rotavirus and coronavirus)
Loss of absorptive capability and loss of brush border enzymes (e.g., disaccharidases) leads to osmotic diarrhea.
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