DEFINITION
Destruction of the oral epithelium, exposing underlying connective tissue
PATHOPHYSIOLOGY
Cell—cell and cell—matrix adhesion proteins are responsible for maintaining the integrity of the mucosal lining of the oral cavity.
Disease processes that destroy keratinocytes or adversely affect their adhesion to one another or to the subjacent basement membrane result in erosions, ulcerations, and desquamation.
Immunologic processes that have a deleterious effect on the integrity of the epithelial—basement membrane submucosa complex may be involved in causing ulcers to form.
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